Reactome | Inactivation, recovery and regulation of the phototransduction cascade

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Inactivation, recovery and regulation of the phototransduction cascade Show undefined attributes

authored	[InstanceEdit:2514885] Jassal, B, 2012-10-11
created	[InstanceEdit:2514885] Jassal, B, 2012-10-11
dbId	2514859
displayName	Inactivation, recovery and regulation of the phototransduction cascade
edited	[InstanceEdit:2514885] Jassal, B, 2012-10-11
eventOf	[Pathway:R-HSA-2514856] The phototransduction cascade - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:260187] regulation of opsin-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2534096] METAP1/2 demethylates GNAT1 - Homo sapiens [Reaction:R-HSA-2534087] NMT1/2 transfer MYS to GNAT1 - Homo sapiens [Reaction:R-HSA-2530501] FNTA:FNTB transfers FARN to GNGT1 - Homo sapiens [BlackBoxEvent:R-HSA-2534040] Unknown NAT N-acylates Gly in GNAT1 - Homo sapiens [Reaction:R-HSA-2581474] GRK1,4,7 phosphorylate MII to p-MII - Homo sapiens [Reaction:R-HSA-3229213] RCVRN:Ca2+ binds to and inhibits GRK1 - Homo sapiens [Reaction:R-HSA-2581488] SAG binds p-MII to form p-MII:SAG - Homo sapiens [Reaction:R-HSA-2632521] at-retinyl is hydrolysed from p-MII:SAG to release atRAL - Homo sapiens [Reaction:R-HSA-74947] p-MII:SAG dissociates to p-RHO and SAG - Homo sapiens [Reaction:R-HSA-74948] PP2A dephosphorylates p-RHO to RHO - Homo sapiens [Reaction:R-HSA-2584246] GNAT1-GTP hydrolyses its bound GTP to GDP - Homo sapiens [Reaction:R-HSA-74615] PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP - Homo sapiens [Reaction:R-HSA-74882] GNAT1-GDP binds to GNB1:GNGT1 - Homo sapiens [Reaction:R-HSA-2586748] GUCA binds Ca2+ to form GUCA:Ca2+ - Homo sapiens [Reaction:R-HSA-74885] GUCYs converts GTP to cGMP - Homo sapiens [Reaction:R-HSA-74031] cGMP binds CNG channel to form cGMP:CNG channel - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens [Reaction:R-HSA-3229181] CALM1:Ca2+ binds CNG channel - Homo sapiens [Reaction:R-HSA-6786205] KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:3222186] Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models [LiteratureReference:3222200] Lessons from photoreceptors: turning off G-protein signaling in living cells
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Inactivation, recovery and regulation of the phototransduction cascade
orthologousEvent	[Pathway:R-RNO-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Rattus norvegicus [Pathway:R-CFA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Canis familiaris [Pathway:R-BTA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Bos taurus [Pathway:R-SSC-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Sus scrofa [Pathway:R-DRE-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Danio rerio [Pathway:R-XTR-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Xenopus tropicalis [Pathway:R-GGA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Gallus gallus [Pathway:R-DME-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Drosophila melanogaster [Pathway:R-CEL-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Caenorhabditis elegans [Pathway:R-DDI-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Dictyostelium discoideum [Pathway:R-SPO-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Schizosaccharomyces pombe [Pathway:R-SCE-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Saccharomyces cerevisiae [Pathway:R-MMU-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Mus musculus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2514859
summation	[Summation:2581485] To terminate the single photon response and restore the syst...
updateTrackers	[UpdateTracker:9911080] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v89:[updateContainedRLE] [UpdateTracker:9780608] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v62:[updateContainedRLE] [UpdateTracker:9783827] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v55:[addHasEvent, updateContainedRLE] [UpdateTracker:9786703] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v48:[updateContainedRLE] [UpdateTracker:9786180] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v50:[updateContainedRLE] [UpdateTracker:9780121] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v64:[updateContainedRLE] [UpdateTracker:9778817] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v67:[updateContainedRLE] [UpdateTracker:9846677] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v84:[updateContainedRLE] [UpdateTracker:9784138] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v54:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-2514856] The phototransduction cascade

(updatedInstance)

[UpdateTracker:9911080] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v89:[updateContainedRLE]
[UpdateTracker:9780608] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v62:[updateContainedRLE]
[UpdateTracker:9783827] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v55:[addHasEvent, updateContainedRLE]
[UpdateTracker:9786703] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v48:[updateContainedRLE]
[UpdateTracker:9786180] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v50:[updateContainedRLE]
[UpdateTracker:9780121] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v64:[updateContainedRLE]
[UpdateTracker:9778817] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v67:[updateContainedRLE]
[UpdateTracker:9846677] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v84:[updateContainedRLE]
[UpdateTracker:9784138] Update Tracker - [Pathway:2514859] Inactivation, recovery and regulation of the phototransduction cascade - v54:[updateContainedRLE]

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