Reactome | GRK1,4,7 phosphorylate MII to p-MII

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GRK1,4,7 phosphorylate MII to p-MII Show undefined attributes

authored	[InstanceEdit:2581471] Jassal, Bijay, 2012-11-13
catalystActivity	[CatalystActivity:2581483] rhodopsin kinase activity of GRK1,4,7 [photoreceptor disc membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:2514888] photoreceptor disc membrane
created	[InstanceEdit:2581471] Jassal, Bijay, 2012-11-13
dbId	2581474
displayName	GRK1,4,7 phosphorylate MII to p-MII
edited	[InstanceEdit:2581471] Jassal, Bijay, 2012-11-13
eventOf	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-2581488] SAG binds p-MII to form p-MII:SAG - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5205901] at-retinyl-RHO [photoreceptor disc membrane] 3 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3223220] Characterization and chromosomal localization of the gene for human rhodopsin kinase [LiteratureReference:3222200] Lessons from photoreceptors: turning off G-protein signaling in living cells [LiteratureReference:3222186] Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models [LiteratureReference:74644] The sequence of human retinal S-antigen reveals similarities with alpha-transducin. [LiteratureReference:3229203] Isolation of human retinal genes: recoverin cDNA and gene [LiteratureReference:6787786] Characterization of human GRK7 as a potential cone opsin kinase [LiteratureReference:2581487] Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities [LiteratureReference:6787780] Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light [LiteratureReference:6787788] Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GRK1,4,7 phosphorylate MII to p-MII GRK1 phosphorylates MII to p-S334,S338,S343-MII
orthologousEvent	[Reaction:R-GGA-2581474] GRK1,4,7 phosphorylate MII to p-MII - Gallus gallus [Reaction:R-XTR-2581474] GRK1,4,7 phosphorylate MII to p-MII - Xenopus tropicalis [Reaction:R-DRE-2581474] GRK1,4,7 phosphorylate MII to p-MII - Danio rerio [Reaction:R-SSC-2581474] GRK1,4,7 phosphorylate MII to p-MII - Sus scrofa [Reaction:R-BTA-2581474] GRK1,4,7 phosphorylate MII to p-MII - Bos taurus [Reaction:R-CFA-2581474] GRK1,4,7 phosphorylate MII to p-MII - Canis familiaris [Reaction:R-RNO-2581474] GRK1,4,7 phosphorylate MII to p-MII - Rattus norvegicus [Reaction:R-MMU-2581474] GRK1,4,7 phosphorylate MII to p-MII - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-5205903] p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane]
precedingEvent	[Reaction:R-HSA-74101] Photons induce isomerization of 11c-retinyl to at-retinyl - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-3223247] Negative regulation by 'S-farn-GRK1:RCVRN:Ca2+ [photoreceptor disc membrane]' [NegativeRegulation:R-HSA-3223249] Negative regulation by 'Ca2+ [cytosol]' [NegativeRegulation:R-HSA-5603166] Negative regulation by 'p-MII:SAG [photoreceptor disc membrane]'
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
revised	[InstanceEdit:6787760] Jassal, Bijay, 2015-07-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2581474
summation	[Summation:2581489] Activated rhodopsin (MII aka R*) must be deactivated to term...
updateTrackers	[UpdateTracker:9786007] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v50:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9784338] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v54:[addLiteratureReference, modifyText] [UpdateTracker:9786752] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v48:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9786007] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v50:[addLiteratureReference, add_removeRegulator, modifyText] [UpdateTracker:9784338] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v54:[addLiteratureReference, modifyText] [UpdateTracker:9786752] Update Tracker - [Reaction:2581474] GRK1,4,7 phosphorylate MII to p-MII - v48:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade
(precedingEvent)	[Reaction:R-HSA-2581488] SAG binds p-MII to form p-MII:SAG

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