Inactivation, recovery and regulation of the phototransduction cascade

Stable Identifier
R-HSA-2514859
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Inactivation, recovery and regulation of the phototransduction cascade
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To terminate the single photon response and restore the system to its basal state, the three activated intermediates in phototransduction, rhodopsin (MII), transducin alpha subunit with GTP bound (GNAT1-GTP) and phosphodiesterase 6 (PDE6) all need to be efficiently deactivated. In addition, the cGMP concentrations must be restored to support reopening of the CNG channels. This section describes the inactivation and recovery events of the activated intermediates involved in phototransduction (Burns & Pugh 2010, Korenbrot 2012).
Literature References
PubMed ID Title Journal Year
20430952 Lessons from photoreceptors: turning off G-protein signaling in living cells

Pugh, EN, Burns, ME

Physiology (Bethesda) 2010
22658984 Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models

Korenbrot, JI

Prog Retin Eye Res 2012
Participants
Events
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Event Information
Go Biological Process
regulation of opsin-mediated signaling pathway (0022400)
Orthologous Events
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Canis familiaris)
Inactivation, recovery and regulation of the phototransduction cascade (Danio rerio)
Inactivation, recovery and regulation of the phototransduction cascade (Dictyostelium discoideum)
Inactivation, recovery and regulation of the phototransduction cascade (Drosophila melanogaster)
Inactivation, recovery and regulation of the phototransduction cascade (Gallus gallus)
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
Inactivation, recovery and regulation of the phototransduction cascade (Rattus norvegicus)
Inactivation, recovery and regulation of the phototransduction cascade (Saccharomyces cerevisiae)
Inactivation, recovery and regulation of the phototransduction cascade (Schizosaccharomyces pombe)
Inactivation, recovery and regulation of the phototransduction cascade (Sus scrofa)
Inactivation, recovery and regulation of the phototransduction cascade (Xenopus tropicalis)
Authored
Jassal, B  (2012-10-11)
Reviewed
Makino, C  (2013-04-11)
Created
Jassal, B  (2012-10-11)
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