Reactome | CALM1:Ca2+ binds CNG channel

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CALM1:Ca2+ binds CNG channel Show undefined attributes

authored	[InstanceEdit:3229194] Jassal, Bijay, 2013-03-26
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3229194] Jassal, Bijay, 2013-03-26
dbId	3229181
displayName	CALM1:Ca2+ binds CNG channel
edited	[InstanceEdit:3229194] Jassal, Bijay, 2013-03-26
eventOf	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Homo sapiens
input	[Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol] [Complex:R-HSA-74001] CNG channel [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:74025] Subunit 2 (or beta) of retinal rod cGMP-gated cation channel is a component of the 240-kDa channel-associated protein and mediates Ca(2+)-calmodulin modulation. [LiteratureReference:74024] Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin. [LiteratureReference:3262459] Interaction of calmodulin with the cyclic GMP-gated channel of rod photoreceptor cells. Modulation of activity, affinity purification, and localization
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CALM1:Ca2+ binds CNG channel Calmodulin:Ca2+ lowers CNG channel sensitivity to cGMP
orthologousEvent	[Reaction:R-MMU-3229181] CALM1:Ca2+ binds CNG channel - Mus musculus [Reaction:R-CEL-3229181] CALM1:Ca2+ binds CNG channel - Caenorhabditis elegans [Reaction:R-DME-3229181] CALM1:Ca2+ binds CNG channel - Drosophila melanogaster [Reaction:R-BTA-3229181] CALM1:Ca2+ binds CNG channel - Bos taurus [Reaction:R-CFA-3229181] CALM1:Ca2+ binds CNG channel - Canis familiaris [Reaction:R-RNO-3229181] CALM1:Ca2+ binds CNG channel - Rattus norvegicus
output	[Complex:R-HSA-3229184] CALM1:Ca2+:CNG channel [plasma membrane]
regulatedBy	[PositiveRegulation:R-HSA-3229230] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3229181
summation	[Summation:3229202] As the channels reopen, rising Ca2+ levels result in binding...
updateTrackers	[UpdateTracker:9783939] Update Tracker - [Reaction:3229181] CALM1:Ca2+ binds CNG channel - v55:[add_removeInput] [UpdateTracker:9786727] Update Tracker - [Reaction:3229181] CALM1:Ca2+ binds CNG channel - v48:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9783939] Update Tracker - [Reaction:3229181] CALM1:Ca2+ binds CNG channel - v55:[add_removeInput] [UpdateTracker:9786727] Update Tracker - [Reaction:3229181] CALM1:Ca2+ binds CNG channel - v48:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-2514859] Inactivation, recovery and regulation of the phototransduction cascade