Reactome | Activation of gene expression by SREBF (SREBP)

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Activation of gene expression by SREBF (SREBP) Show undefined attributes

authored	[InstanceEdit:2426159] May, B, 2012-07-26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2426167] May, B, 2012-07-27
dbId	2426168
displayName	Activation of gene expression by SREBF (SREBP)
edited	[InstanceEdit:2426159] May, B, 2012-07-26
eventOf	[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8634] regulation of lipid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2426160] SREBP1A,1C,2 binds the ACACA promoter - Homo sapiens [Reaction:R-HSA-2426153] SREBP1A,1C binds the ACACB promoter - Homo sapiens [Reaction:R-HSA-2065966] SREBP1A,1C,2 binds the TM7SF2 promoter - Homo sapiens [Reaction:R-HSA-2426158] SREBP1A,1C binds the GPAM promoter - Homo sapiens [Reaction:R-HSA-2426148] SREBP1A,1C binds the FASN promoter - Homo sapiens [Reaction:R-HSA-6800052] SREBP1A,1C binds the SCD gene - Homo sapiens [Reaction:R-HSA-2426154] SREBP1A,2 binds the LSS promoter - Homo sapiens [Reaction:R-HSA-2426144] SREBP1A,2 binds the MVD promoter - Homo sapiens [Reaction:R-HSA-2426162] SREBP1A,2 binds the HMGCR promoter - Homo sapiens [Reaction:R-HSA-2426164] SREBP1A,2 binds the SC5DL promoter - Homo sapiens [Reaction:R-HSA-2426163] SREBP1A,2 binds the CYP51A1 promoter - Homo sapiens [Reaction:R-HSA-2426155] SREBP1A,2 binds the DHCR7 promoter - Homo sapiens [Reaction:R-HSA-2426161] SREBP1A,2 binds the GGPS1 promoter - Homo sapiens [Reaction:R-HSA-2426152] SREBP1A,2 binds the IDI1 promoter - Homo sapiens [Reaction:R-HSA-2426157] SREBP1A,2 binds the MVK promoter - Homo sapiens [Reaction:R-HSA-2426156] SREBP1A,2 binds the PMVK promoter - Homo sapiens [Reaction:R-HSA-2426151] SREBP1A,2 binds the SQLE promoter - Homo sapiens [Reaction:R-HSA-2426149] SREBP1A,1C,2 binds the ELOVL6 promoter - Homo sapiens [Reaction:R-HSA-2426147] SREBP1A,1C,2 binds the FDPS promoter - Homo sapiens [Reaction:R-HSA-2426150] SREBP1A,1C,2 binds the HMGCS1 promoter - Homo sapiens [Reaction:R-HSA-2426146] SREBP1A,1C,2 binds the FDFT1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-1655826] Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) - Homo sapiens [BlackBoxEvent:R-HSA-1655827] Expression of 7-Dehydrocholesterol Reductase (DHCR7) - Homo sapiens [BlackBoxEvent:R-HSA-1655845] Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) - Homo sapiens [BlackBoxEvent:R-HSA-1655830] Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) - Homo sapiens [BlackBoxEvent:R-HSA-1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - Homo sapiens [BlackBoxEvent:R-HSA-1655836] Expression of Diphosphomevalonate Decarboxylase (MVD) - Homo sapiens [BlackBoxEvent:R-HSA-1655835] Expression of ELOVL6 - Homo sapiens [BlackBoxEvent:R-HSA-1655824] Expression of Farnesyl Diphosphate Synthase (FDPS) - Homo sapiens [BlackBoxEvent:R-HSA-1655850] Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) - Homo sapiens [BlackBoxEvent:R-HSA-1655843] Expression of Fatty Acid Synthase (FASN) - Homo sapiens [BlackBoxEvent:R-HSA-1655832] Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) - Homo sapiens [BlackBoxEvent:R-HSA-1655837] Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) - Homo sapiens [BlackBoxEvent:R-HSA-1655848] Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) - Homo sapiens [BlackBoxEvent:R-HSA-1655823] Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) - Homo sapiens [BlackBoxEvent:R-HSA-1655847] Expression of Lanosterol Demethylase (CYP51A1) - Homo sapiens [BlackBoxEvent:R-HSA-1655828] Expression of Lanosterol Synthase (LSS) - Homo sapiens [BlackBoxEvent:R-HSA-1655852] Expression of Lathosterol Oxidase (SC5D, SC5DL) - Homo sapiens [BlackBoxEvent:R-HSA-1655846] Expression of Mevalonate Kinase (MVK) - Homo sapiens [BlackBoxEvent:R-HSA-1655839] Expression of Phosphomevalonate Kinase (PMVK) - Homo sapiens [BlackBoxEvent:R-HSA-1655844] Expression of Squalene Monooxygenase (SQLE) - Homo sapiens [BlackBoxEvent:R-HSA-1655833] Expression of TM7SF2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:2426210] SREBP transcription factors: master regulators of lipid homeostasis [LiteratureReference:1655609] Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins [LiteratureReference:1655530] Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Activation of gene expression by SREBF (SREBP)
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2457630] Liang, Guosheng, 2012-08-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2426168
summation	[Summation:2426219] After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs...
updateTrackers	[UpdateTracker:9776049] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v78:[updateContainedRLE] [UpdateTracker:9785257] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v52:[updateContainedRLE] [UpdateTracker:9779509] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v65:[updateContainedRLE] [UpdateTracker:9782848] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v58:[updateContainedRLE] [UpdateTracker:9783760] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v55:[addHasEvent] [UpdateTracker:9781968] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v60:[updateContainedRLE] [UpdateTracker:9786687] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v49:[updateContainedRLE] [UpdateTracker:9780138] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v64:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)

(updatedInstance)

[UpdateTracker:9776049] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v78:[updateContainedRLE]
[UpdateTracker:9785257] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v52:[updateContainedRLE]
[UpdateTracker:9779509] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v65:[updateContainedRLE]
[UpdateTracker:9782848] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v58:[updateContainedRLE]
[UpdateTracker:9783760] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v55:[addHasEvent]
[UpdateTracker:9781968] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v60:[updateContainedRLE]
[UpdateTracker:9786687] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v49:[updateContainedRLE]
[UpdateTracker:9780138] Update Tracker - [Pathway:2426168] Activation of gene expression by SREBF (SREBP) - v64:[updateContainedRLE]

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