Reactome | Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)

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Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) Show undefined attributes

authored	[InstanceEdit:1655770] May, B, 2011-09-28
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:1655841] May, B, 2011-10-13
dbId	1655849
displayName	Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)
edited	[InstanceEdit:1655770] May, B, 2011-09-28
eventOf	[Pathway:R-HSA-2426168] Activation of gene expression by SREBF (SREBP) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
input	[EntityWithAccessionedSequence:R-HSA-6800051] SCD gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1660625] Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues [LiteratureReference:1655604] Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 [LiteratureReference:1655678] Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol
maxDepth	1
modified	[InstanceEdit:9961220] D'Eustachio, Peter, 2025-07-21
name	Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)
output	[EntityWithAccessionedSequence:R-HSA-400117] SCD [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-6800052] SREBP1A,1C binds the SCD gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-1655858] Positive gene expression regulation by 'SREBP1A,1C:SCD gene [nucleoplasm]'
regulationReference	[RegulationReference:9642623] Positive gene expression regulation by 'SREBP1A,1C:SCD gene [nucleoplasm]' SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6800048] May, Bruce, 2015-09-27
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1655849
summation	[Summation:1655787] The SCD gene is transcribed to yield mRNA (Li et al. 1994) a... [Summation:1655803] SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of...
updateTrackers	[UpdateTracker:9779916] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v64:[addRegulator] [UpdateTracker:9779342] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v65:[removeRegulator] [UpdateTracker:9775880] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v78:[addSummation] [UpdateTracker:9781891] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v60:[add_removeInput]

Referrals

(updatedInstance)

[UpdateTracker:9779916] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v64:[addRegulator]
[UpdateTracker:9779342] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v65:[removeRegulator]
[UpdateTracker:9775880] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v78:[addSummation]
[UpdateTracker:9781891] Update Tracker - [BlackBoxEvent:1655849] Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) - v60:[add_removeInput]

(hasEvent)

[Pathway:R-HSA-2426168] Activation of gene expression by SREBF (SREBP)

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