PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1

Stable Identifier
R-HSA-2243937
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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A portion of PDPK1 (PDK1) is anchored to the plasma membrane in the absence of PI3K activity through PIP2 binding (Currie et al. 1999). This PIP2-bound PDPK1 is able to bind and phosphorylate PIP2-bound AKT E17K mutants (Carpten et al. 2007, Landgraf et al. 2008) phosphorylated on serine residue S473.

Literature References
PubMed ID Title Journal Year
18954143 Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

Landgraf, KE, Pilling, C, Falke, JJ

Biochemistry 2008
9895304 Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Currie, RA, Walker, KS, Gray, A, Deak, M, Casamayor, A, Downes, CP, Cohen, P, Alessi, DR, Lucocq, J

Biochem J 1999
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, JD, Faber, AL, Horn, C, Donoho, GP, Briggs, SL, Robbins, CM, Hostetter, G, Boguslawski, S, Moses, TY, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, YW, Zeckner, DJ, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, MHT, Blanchard, KL, Thomas, JE

Nature 2007
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
ovarian cancer 2394 ovarian neoplasm, malignant tumour of ovary, neoplasm of ovary (disorder), ovary neoplasm, primary malignant neoplasm of ovary and other uterine adnexa (disorder), ovarian cancer, tumor of the Ovary, ovary cancer, malignant Ovarian tumor, primary ovarian cancer, malignant tumor of ovary (disorder)
breast cancer 1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer 5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
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