Reactome | abacavir [extracellular] => abacavir [cytosol]

Schema > Reaction > Entries

abacavir [extracellular] => abacavir [cytosol] Show undefined attributes

authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity	[CatalystActivity:2161534] transmembrane transporter activity of SLC22A1,2,3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643998] organic cation transmembrane transporter activity of SLC22A1,2,3 [plasma membrane] Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2161504] D'Eustachio, P, 2012-03-14
dbId	2161500
displayName	abacavir [extracellular] => abacavir [cytosol]
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf	[Pathway:R-HSA-2161517] Abacavir transmembrane transport - Homo sapiens
followingEvent	[Reaction:R-HSA-2161538] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate - Homo sapiens [Reaction:R-HSA-2161506] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate - Homo sapiens [Reaction:R-HSA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Homo sapiens [Reaction:R-HSA-2162099] abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP - Homo sapiens
input	[ChemicalDrug:R-ALL-2161525] abacavir [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161081] Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3 [LiteratureReference:2161518] Xenobiotic, bile acid, and cholesterol transporters: function and regulation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	abacavir [extracellular] => abacavir [cytosol] OCT (organic cation transporter)-mediated abacavir uptake
orthologousEvent	[Reaction:R-CEL-2161500] abacavir [extracellular] => abacavir [cytosol] - Caenorhabditis elegans [Reaction:R-DME-2161500] abacavir [extracellular] => abacavir [cytosol] - Drosophila melanogaster [Reaction:R-GGA-2161500] abacavir [extracellular] => abacavir [cytosol] - Gallus gallus [Reaction:R-XTR-2161500] abacavir [extracellular] => abacavir [cytosol] - Xenopus tropicalis [Reaction:R-DRE-2161500] abacavir [extracellular] => abacavir [cytosol] - Danio rerio [Reaction:R-SSC-2161500] abacavir [extracellular] => abacavir [cytosol] - Sus scrofa [Reaction:R-BTA-2161500] abacavir [extracellular] => abacavir [cytosol] - Bos taurus [Reaction:R-CFA-2161500] abacavir [extracellular] => abacavir [cytosol] - Canis familiaris [Reaction:R-RNO-2161500] abacavir [extracellular] => abacavir [cytosol] - Rattus norvegicus [Reaction:R-MMU-2161500] abacavir [extracellular] => abacavir [cytosol] - Mus musculus
output	[ChemicalDrug:R-ALL-2161185] abacavir [cytosol]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161500
summation	[Summation:2161528] Organic cation transporters 1 (OCT1, SLC22A1), 2 (OCT2, SLC2...

Referrals

(hasEvent)	[Pathway:R-HSA-2161517] Abacavir transmembrane transport
(precedingEvent)	[Reaction:R-HSA-2161538] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate [Reaction:R-HSA-2161506] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate [Reaction:R-HSA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ [Reaction:R-HSA-2162099] abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP

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