Reactome | abacavir [extracellular] => abacavir [cytosol]

Schema > Reaction > Entries

abacavir [extracellular] => abacavir [cytosol] Show undefined attributes

catalystActivity	[CatalystActivity:10956323] transmembrane transporter activity of SLC22A1,2,3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10956325
displayName	abacavir [extracellular] => abacavir [cytosol]
eventOf	[Pathway:R-CEL-2161517] Abacavir transmembrane transport - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-2161500] abacavir [extracellular] => abacavir [cytosol] - Homo sapiens
input	[ChemicalDrug:R-ALL-2161525] abacavir [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	abacavir [extracellular] => abacavir [cytosol] OCT (organic cation transporter)-mediated abacavir uptake
output	[ChemicalDrug:R-ALL-2161185] abacavir [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2161500
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2161517] Abacavir transmembrane transport
(precedingEvent)	[Reaction:R-CEL-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+
(inferredTo)	[Reaction:R-HSA-2161500] abacavir [extracellular] => abacavir [cytosol]

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