Reactome | Abacavir transmembrane transport

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Abacavir transmembrane transport Show undefined attributes

authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
created	[InstanceEdit:2161504] D'Eustachio, P, 2012-03-14
dbId	2161517
displayName	Abacavir transmembrane transport
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf	[Pathway:R-HSA-2161522] Abacavir ADME - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1221246] purine-containing compound transmembrane transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2161500] abacavir [extracellular] => abacavir [cytosol] - Homo sapiens [Reaction:R-HSA-2161506] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate - Homo sapiens [Reaction:R-HSA-2161538] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161518] Xenobiotic, bile acid, and cholesterol transporters: function and regulation [LiteratureReference:2161079] Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine [LiteratureReference:2161095] P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Abacavir transmembrane transport
orthologousEvent	[Pathway:R-CEL-2161517] Abacavir transmembrane transport - Caenorhabditis elegans [Pathway:R-DME-2161517] Abacavir transmembrane transport - Drosophila melanogaster [Pathway:R-GGA-2161517] Abacavir transmembrane transport - Gallus gallus [Pathway:R-XTR-2161517] Abacavir transmembrane transport - Xenopus tropicalis [Pathway:R-DRE-2161517] Abacavir transmembrane transport - Danio rerio [Pathway:R-SSC-2161517] Abacavir transmembrane transport - Sus scrofa [Pathway:R-BTA-2161517] Abacavir transmembrane transport - Bos taurus [Pathway:R-CFA-2161517] Abacavir transmembrane transport - Canis familiaris [Pathway:R-RNO-2161517] Abacavir transmembrane transport - Rattus norvegicus [Pathway:R-MMU-2161517] Abacavir transmembrane transport - Mus musculus
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2161517
summation	[Summation:2161530] Cytosolic levels of abacavir are determined by the balance o...

Referrals

(hasEvent)

[Pathway:R-HSA-2161522] Abacavir ADME