Reactome | abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+

Schema > Reaction > Entries

abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ Show undefined attributes

authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity	[CatalystActivity:2162089] alcohol dehydrogenase (NAD+) activity of ADH1A:2Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2162100] D'Eustachio, P, 2012-03-14
dbId	2162078
displayName	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf	[Pathway:R-HSA-2161541] Abacavir metabolism - Homo sapiens
input	[ChemicalDrug:R-ALL-2161185] abacavir [cytosol] 2 × [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162064] The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ Oxidation of abacavir to abacavir 5'-carboxylate
orthologousEvent	[Reaction:R-SCE-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Saccharomyces cerevisiae [Reaction:R-SPO-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Schizosaccharomyces pombe [Reaction:R-DDI-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Dictyostelium discoideum [Reaction:R-CEL-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Caenorhabditis elegans [Reaction:R-DME-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Drosophila melanogaster [Reaction:R-GGA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Gallus gallus [Reaction:R-XTR-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Xenopus tropicalis [Reaction:R-DRE-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Danio rerio [Reaction:R-SSC-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Sus scrofa [Reaction:R-BTA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Bos taurus [Reaction:R-CFA-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Canis familiaris [Reaction:R-RNO-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Rattus norvegicus [Reaction:R-MMU-2162078] abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ - Mus musculus
output	[SimpleEntity:R-ALL-2162081] abacavir 5'-carboxylic acid [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-HSA-2161500] abacavir [extracellular] => abacavir [cytosol] - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162078
summation	[Summation:2162061] Cytosolic ADH alpha dimer catalyzes the reaction of abacavir...

Referrals

(hasEvent)

[Pathway:R-HSA-2161541] Abacavir metabolism