abacavir [extracellular] => abacavir [cytosol]

Stable Identifier
R-HSA-2161500
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
OCT (organic cation transporter)-mediated abacavir uptake
Locations in the PathwayBrowser
General
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Organic cation transporters 1 (OCT1, SLC22A1), 2 (OCT2, SLC22A2) and 3 (OCT3, SLC22A3) associated with the plasma membrane all mediate the influx of abacavir. The three transporters have similar affinities for abacavir (Minuesa et al. 2009) but differ in the tissues in which they are expressed and in their distributions on the surfaces of polarized cells (reviewed by Klaasen and Aleksunes 2010).

Literature References
PubMed ID Title Journal Year
19141712 Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3

Minuesa, G, Volk, C, Molina-Arcas, M, Gorboulev, V, Erkizia, I, Arndt, P, Clotet, B, Pastor-Anglada, M, Koepsell, H, Martinez-Picado, J

J Pharmacol Exp Ther 2009
20103563 Xenobiotic, bile acid, and cholesterol transporters: function and regulation

Klaassen, CD, Aleksunes, LM

Pharmacol Rev 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
organic cation transmembrane transporter activity of SLC22A1,2,3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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