Reactome | abacavir [extracellular] => abacavir [cytosol]

abacavir [extracellular] => abacavir [cytosol]

Stable Identifier

R-HSA-2161500

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

OCT (organic cation transporter)-mediated abacavir uptake

ReviewStatus

5/5

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abacavir [extracellular] => abacavir [cytosol]

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Organic cation transporters 1 (OCT1, SLC22A1), 2 (OCT2, SLC22A2) and 3 (OCT3, SLC22A3) associated with the plasma membrane all mediate the influx of abacavir. The three transporters have similar affinities for abacavir (Minuesa et al. 2009) but differ in the tissues in which they are expressed and in their distributions on the surfaces of polarized cells (reviewed by Klaasen and Aleksunes 2010).

Literature References

PubMed ID	Title	Journal	Year
20103563	Xenobiotic, bile acid, and cholesterol transporters: function and regulation Klaassen, CD, Aleksunes, LM	Pharmacol Rev	2010
19141712	Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3 Minuesa, G, Volk, C, Molina-Arcas, M, Gorboulev, V, Erkizia, I, Arndt, P, Clotet, B, Pastor-Anglada, M, Koepsell, H, Martinez-Picado, J	J Pharmacol Exp Ther	2009