Reactome | abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Schema > Reaction > Entries

abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate Show undefined attributes

authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity	[CatalystActivity:2161511] ATPase-coupled transmembrane transporter activity of ABCB1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2161504] D'Eustachio, P, 2012-03-14
dbId	2161538
displayName	abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf	[Pathway:R-HSA-2161517] Abacavir transmembrane transport - Homo sapiens
inferredFrom	[Reaction:R-MMU-2161526] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate - Mus musculus
input	[ChemicalDrug:R-ALL-2161185] abacavir [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2161095] P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate ABCB1-mediated abacavir efflux
output	[ChemicalDrug:R-ALL-2161525] abacavir [extracellular region] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-2161500] abacavir [extracellular] => abacavir [cytosol] - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161538
summation	[Summation:2161516] The ABCB1 transporter associated with the plasma membrane me...

Referrals

(hasEvent)	[Pathway:R-HSA-2161517] Abacavir transmembrane transport
(inferredTo)	[Reaction:R-MMU-2161526] abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

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