Reactome | Active PLC-gamma1 dissociates from EGFR

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Active PLC-gamma1 dissociates from EGFR Show undefined attributes

authored	[InstanceEdit:212714] Jassal, Bijay, 2008-02-13
category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:212707] Jassal, Bijay, 2008-02-13
dbId	212713
diseaseReaction	[Reaction:R-HSA-5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant - Homo sapiens [Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - Homo sapiens
displayName	Active PLC-gamma1 dissociates from EGFR
eventOf	[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens
followingEvent	[Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens
input	[Complex:R-HSA-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Active PLC-gamma1 dissociates from EGFR
orthologousEvent	[Reaction:R-CEL-212713] Active PLC-gamma1 dissociates from EGFR - Caenorhabditis elegans [Reaction:R-DME-212713] Active PLC-gamma1 dissociates from EGFR - Drosophila melanogaster [Reaction:R-GGA-212713] Active PLC-gamma1 dissociates from EGFR - Gallus gallus [Reaction:R-XTR-212713] Active PLC-gamma1 dissociates from EGFR - Xenopus tropicalis [Reaction:R-DRE-212713] Active PLC-gamma1 dissociates from EGFR - Danio rerio [Reaction:R-SSC-212713] Active PLC-gamma1 dissociates from EGFR - Sus scrofa [Reaction:R-BTA-212713] Active PLC-gamma1 dissociates from EGFR - Bos taurus [Reaction:R-CFA-212713] Active PLC-gamma1 dissociates from EGFR - Canis familiaris [Reaction:R-RNO-212713] Active PLC-gamma1 dissociates from EGFR - Rattus norvegicus [Reaction:R-MMU-212713] Active PLC-gamma1 dissociates from EGFR - Mus musculus
output	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-212713
summation	[Summation:213061] Once activated PLC-gamma1 dissociates from EGFR, it can hydr...
updateTrackers	[UpdateTracker:9778930] Update Tracker - [Reaction:212713] Active PLC-gamma1 dissociates from EGFR - v67:[add_removeOutput] [UpdateTracker:9788991] Update Tracker - [Reaction:212713] Active PLC-gamma1 dissociates from EGFR - v39:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9778930] Update Tracker - [Reaction:212713] Active PLC-gamma1 dissociates from EGFR - v67:[add_removeOutput] [UpdateTracker:9788991] Update Tracker - [Reaction:212713] Active PLC-gamma1 dissociates from EGFR - v39:[addLiteratureReference]
(normalReaction)	[Reaction:R-HSA-5637800] Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant [Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
(precedingEvent)	[NegativePrecedingEvent:9865818] Futile Cycle: Active PLC-gamma1 dissociates from EGFR [NegativePrecedingEvent:9865820] Futile Cycle: Active PLC-gamma1 dissociates from EGFR [NegativePrecedingEvent:9865815] Futile Cycle: Active PLC-gamma1 dissociates from EGFR [NegativePrecedingEvent:9865822] Futile Cycle: Active PLC-gamma1 dissociates from EGFR [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 [NegativePrecedingEvent:9865814] Futile Cycle: Active PLC-gamma1 dissociates from EGFR [NegativePrecedingEvent:9865810] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
(hasEvent)	[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma

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