Reactome | EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:212705] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation - Homo sapiens
created	[InstanceEdit:212707] Jassal, Bijay, 2008-02-13
dbId	212717
displayName	EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
hasComponent	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-202320] PLCG1 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Mus musculus [Complex:R-RNO-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Canis familiaris [Complex:R-BTA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Bos taurus [Complex:R-SSC-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Sus scrofa [Complex:R-DRE-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Danio rerio [Complex:R-XTR-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Gallus gallus [Complex:R-DME-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - Caenorhabditis elegans
maxDepth	4
modified	[InstanceEdit:9624452] Rothfels, Karen, 2018-10-11
name	EGF-like ligands:p-6Y-EGFR:PLCG1 Activated EGFR:PLC-gamma1
producedByEvent	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-212717
updateTrackers	[UpdateTracker:9870610] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v38:[addName, updateContainedComponent] [UpdateTracker:9871497] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v40:[addCompartment] [UpdateTracker:9871205] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9894665] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9872435] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9899926] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v67:[add_removeHasComponent, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9870610] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v38:[addName, updateContainedComponent] [UpdateTracker:9871497] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v40:[addCompartment] [UpdateTracker:9871205] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9894665] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v57:[updateContainedComponent] [UpdateTracker:9872435] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v41:[removeCompartment, updateContainedComponent] [UpdateTracker:9899926] Update Tracker - [Complex:212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] - v67:[add_removeHasComponent, modifyName]
(normalEntity)	[EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane] [EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
(output)	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
(input)	[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation
(physicalEntity)	[CatalystActivity:212705] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

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