EGFR activates PLC-gamma1 by phosphorylation

Stable Identifier
R-HSA-212710
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EGFR phosphorylates PLC-gamma1, thus activating it.

Literature References
PubMed ID Title Journal Year
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Wahl, MI, Nishibe, S, Kim, JW, Kim, H, Rhee, SG, Carpenter, G

J Biol Chem 1990
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Suh, PG, Rhee, SG, Hunter, T

Cell 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created