EGFR activates PLC-gamma1 by phosphorylation

Stable Identifier
R-HSA-212710
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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EGFR phosphorylates PLC-gamma1, thus activating it.
Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Rhee, SG, Suh, PG, Hunter, T

Cell 1989
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Kim, JW, Rhee, SG, Wahl, MI, Kim, H, Nishibe, S, Carpenter, G

J Biol Chem 1990
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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