EGFR activates PLC-gamma1 by phosphorylation

Stable Identifier
R-HSA-212710
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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EGFR activates PLC-gamma1 by phosphorylation
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EGFR phosphorylates PLC-gamma1, thus activating it.
Literature References
PubMed ID Title Journal Year
2472219 Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

Meisenhelder, J, Suh, PG, Rhee, SG, Hunter, T

Cell 1989
1689311 Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells

Wahl, MI, Nishibe, S, Kim, JW, Kim, H, Rhee, SG, Carpenter, G

J Biol Chem 1990
Participants
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Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)
EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)
EGFR activates PLC-gamma1 by phosphorylation (Danio rerio)
EGFR activates PLC-gamma1 by phosphorylation (Drosophila melanogaster)
EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)
EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)
EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)
EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)
EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)
Authored
Jassal, B  (2008-02-13)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2008-02-13)
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