Reactome | HS6STs sulfate GlcN at C6 in heparan sulfate/heparin

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HS6STs sulfate GlcN at C6 in heparan sulfate/heparin Show undefined attributes

catalystActivity	[CatalystActivity:10955189] heparan sulfate 6-sulfotransferase activity of HS6STs [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10955191
displayName	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
eventOf	[Pathway:R-CEL-2022928] HS-GAG biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CEL-2024108] Some HSPGs are secreted to the plasma membrane - Caenorhabditis elegans
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
inferredFrom	[Reaction:R-HSA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Homo sapiens
input	[DefinedSet:R-CEL-2076461] HS(5)-PGs [Golgi lumen] [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-CEL-2076357] HS/HPIN-PGs [Golgi lumen] [SimpleEntity:R-ALL-742343] PAP [Golgi lumen]
precedingEvent	[Reaction:R-CEL-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-2076419
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-2022928] HS-GAG biosynthesis
(precedingEvent)	[BlackBoxEvent:R-CEL-2024108] Some HSPGs are secreted to the plasma membrane
(inferredTo)	[Reaction:R-HSA-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin

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