Reactome | YAP1- and WWTR1 (TAZ)-stimulated gene expression

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YAP1- and WWTR1 (TAZ)-stimulated gene expression Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:2032782] D'Eustachio, P, 2012-01-06
dbId	2032785
displayName	YAP1- and WWTR1 (TAZ)-stimulated gene expression
doi	10.3180/REACT_118713.1
edited	[InstanceEdit:2032771] D'Eustachio, P, 2012-01-06
eventOf	[Pathway:R-HSA-212436] Generic Transcription Pathway - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17841] transcription initiation at RNA polymerase II promoter
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-2032781] WWTR1 (TAZ) binds TEAD - Homo sapiens [Reaction:R-HSA-2032775] YAP1 binds TEAD1 - Homo sapiens [Reaction:R-HSA-8871260] YAP1 binds TEAD2 - Homo sapiens [Reaction:R-HSA-8871266] YAP1 binds TEAD3 - Homo sapiens [Reaction:R-HSA-8871265] YAP1 binds TEAD4 - Homo sapiens [Reaction:R-HSA-2032794] WWTR1 (TAZ), TBX5, and PCAF form a complex - Homo sapiens [Reaction:R-HSA-2064932] WWTR1 (TAZ) binds RUNX2 - Homo sapiens [BlackBoxEvent:R-HSA-1989766] Expression of CTGF - Homo sapiens [BlackBoxEvent:R-HSA-2032800] Expression of NPPA (ANF) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:2032792] A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome [LiteratureReference:2028572] Yorkie: the final destination of Hippo signaling
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	YAP1- and WWTR1 (TAZ)-stimulated gene expression
orthologousEvent	[Pathway:R-CFA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Canis familiaris [Pathway:R-DME-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Drosophila melanogaster [Pathway:R-CEL-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Caenorhabditis elegans [Pathway:R-GGA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Gallus gallus [Pathway:R-XTR-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Xenopus tropicalis [Pathway:R-DRE-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Danio rerio [Pathway:R-SSC-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Sus scrofa [Pathway:R-BTA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Bos taurus [Pathway:R-RNO-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Rattus norvegicus [Pathway:R-MMU-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Mus musculus
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2032785
summation	[Summation:2032790] YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both...
updateTrackers	[UpdateTracker:9781061] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v61:[updateContainedRLE] [UpdateTracker:9785362] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v52:[updateContainedRLE] [UpdateTracker:9785996] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v50:[updateContainedRLE] [UpdateTracker:9783095] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v57:[addHasEvent, updateContainedRLE] [UpdateTracker:9779886] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v64:[updateContainedRLE] [UpdateTracker:9780596] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v62:[updateContainedRLE] [UpdateTracker:9781860] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v60:[updateContainedRLE] [UpdateTracker:9784120] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v54:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781061] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v61:[updateContainedRLE] [UpdateTracker:9785362] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v52:[updateContainedRLE] [UpdateTracker:9785996] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v50:[updateContainedRLE] [UpdateTracker:9783095] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v57:[addHasEvent, updateContainedRLE] [UpdateTracker:9779886] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v64:[updateContainedRLE] [UpdateTracker:9780596] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v62:[updateContainedRLE] [UpdateTracker:9781860] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v60:[updateContainedRLE] [UpdateTracker:9784120] Update Tracker - [Pathway:2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - v54:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-212436] Generic Transcription Pathway
(hasEncapsulatedEvent)	[Pathway:R-HSA-1236394] Signaling by ERBB4 [Pathway:R-HSA-2028269] Signaling by Hippo

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