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YAP1- and WWTR1 (TAZ)-stimulated gene expression
Stable Identifier
R-HSA-2032785
DOI
10.3180/REACT_118713.1
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
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YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010).
Literature References
PubMed ID
Title
Journal
Year
16332960
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
Murakami, M
,
Olson, EN
,
Nakagawa, O
,
Nakagawa, M
Proc Natl Acad Sci U S A
2005
20452772
Yorkie: the final destination of Hippo signaling
Oh, H
,
Irvine, KD
Trends Cell Biol
2010
Participants
Events
WWTR1 (TAZ) binds TEAD
(Homo sapiens)
YAP1 binds TEAD1
(Homo sapiens)
YAP1 binds TEAD2
(Homo sapiens)
YAP1 binds TEAD3
(Homo sapiens)
YAP1 binds TEAD4
(Homo sapiens)
WWTR1 (TAZ), TBX5, and PCAF form a complex
(Homo sapiens)
WWTR1 (TAZ) binds RUNX2
(Homo sapiens)
Expression of CTGF
(Homo sapiens)
Expression of NPPA (ANF)
(Homo sapiens)
Participates
as an event of
Generic Transcription Pathway (Homo sapiens)
Event Information
Go Biological Process
transcription initiation at RNA polymerase II promoter (0006367)
Orthologous Events
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Bos taurus)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Caenorhabditis elegans)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Canis familiaris)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Danio rerio)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Gallus gallus)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Mus musculus)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Rattus norvegicus)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Sus scrofa)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Xenopus tropicalis)
Authored
D'Eustachio, P (2012-02-03)
Reviewed
Sudol, M (2012-02-03)
Created
D'Eustachio, P (2012-01-07)
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