Reactome | Expression of NPPA (ANF)

Schema > BlackBoxEvent > Entries

Expression of NPPA (ANF) Show undefined attributes

authored	[InstanceEdit:2085531] D'Eustachio, P, 2012-02-03
category	omitted
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2032793] D'Eustachio, P, 2012-01-07
dbId	2032800
displayName	Expression of NPPA (ANF)
edited	[InstanceEdit:2032782] D'Eustachio, P, 2012-01-06
eventOf	[Pathway:R-HSA-5578768] Physiological factors - Homo sapiens [Pathway:R-HSA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6787314] NPPA gene [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2032792] A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome [LiteratureReference:5578844] The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression [LiteratureReference:5578851] Congenital heart disease caused by mutations in the transcription factor NKX2-5 [LiteratureReference:5578868] Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of NPPA (ANF)
output	[EntityWithAccessionedSequence:R-HSA-976950] NPPA(1-151) [extracellular region]
precedingEvent	[Reaction:R-HSA-2032794] WWTR1 (TAZ), TBX5, and PCAF form a complex - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-2032803] Positive gene expression regulation by 'TBX5:WWTR1:PCAF [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5578876] Positive gene expression regulation by 'NKX2-5:GATA4:HIPK1,2 [nucleoplasm]'
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2085532] Sudol, M, 2012-02-03
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2032800
summation	[Summation:2032796] Transcription of the NPPA (ANF) gene is stimulated by the ac...
updateTrackers	[UpdateTracker:9784116] Update Tracker - [BlackBoxEvent:2032800] Expression of NPPA (ANF) - v54:[addInput] [UpdateTracker:9785956] Update Tracker - [BlackBoxEvent:2032800] Expression of NPPA (ANF) - v50:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784116] Update Tracker - [BlackBoxEvent:2032800] Expression of NPPA (ANF) - v54:[addInput] [UpdateTracker:9785956] Update Tracker - [BlackBoxEvent:2032800] Expression of NPPA (ANF) - v50:[addLiteratureReference, addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-5578768] Physiological factors [Pathway:R-HSA-2032785] YAP1- and WWTR1 (TAZ)-stimulated gene expression

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