Reactome | Caspase mediated cleavage of APC

Schema > Reaction > Entries

Caspase mediated cleavage of APC Show undefined attributes

catalystActivity	[CatalystActivity:10003785] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10004771
displayName	Caspase mediated cleavage of APC
eventOf	[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-202947] Caspase mediated cleavage of APC - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-2976015] Apc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase mediated cleavage of APC
output	[EntityWithAccessionedSequence:R-MMU-2976014] Apc [cytosol] [EntityWithAccessionedSequence:R-MMU-2976013] Apc [cytosol]
precedingEvent	[Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome - Mus musculus [Reaction:R-MMU-418845] Activation of caspase-3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-202947
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins
(inferredTo)	[Reaction:R-HSA-202947] Caspase mediated cleavage of APC

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