Reactome | Caspase mediated cleavage of APC

Caspase mediated cleavage of APC

Stable Identifier

R-HSA-202947

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cleavage of APC by caspase 3 and release of the amino-terminal fragment (1-760) are required for the APC mediated acceleration of apoptosis-associated caspase activity (Qian et al., 2007).

Literature References

PubMed ID	Title	Journal	Year
10200466	The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases Cohen, GM, Paraskeva, C, MacFarlane, M, Browne, SJ	Cell Death Differ	1998
9973322	Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain Bubb, VJ, Nicholson, D, Webb, SJ, Wyllie, AH	FASEB J	1999
17297457	Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis Combs, KA, Groden, J, Qian, J, Barton, MC, Steigerwald, K	Oncogene	2007