Reactome | Recruitment of ZAP-70 to phosphorylated ITAMs

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Recruitment of ZAP-70 to phosphorylated ITAMs Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202344
displayName	Recruitment of ZAP-70 to phosphorylated ITAMs
eventOf	[Pathway:R-HSA-202430] Translocation of ZAP-70 to Immunological synapse - Homo sapiens
followingEvent	[Reaction:R-HSA-202168] Phosphorylation of ZAP-70 by Lck - Homo sapiens
input	[Complex:R-HSA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-202397] ZAP70 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202253] The Syk family of protein tyrosine kinases in T-cell activation and development [LiteratureReference:202361] The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes [LiteratureReference:202353] Positive and negative regulation of T-cell activation through kinases and phosphatases
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Recruitment of ZAP-70 to phosphorylated ITAMs
orthologousEvent	[Reaction:R-XTR-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Xenopus tropicalis [Reaction:R-BTA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Bos taurus [Reaction:R-CFA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Canis familiaris [Reaction:R-RNO-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Rattus norvegicus [Reaction:R-MMU-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Mus musculus
output	[Complex:R-HSA-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
precedingEvent	[Reaction:R-HSA-202165] Phosphorylation of ITAM motifs in CD3 complexes - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202344
summation	[Summation:202149] Phosphorylation of the ITAMs by Lck is followed by the recru...

Referrals

(hasEvent)	[Pathway:R-HSA-202430] Translocation of ZAP-70 to Immunological synapse
(precedingEvent)	[Reaction:R-HSA-202168] Phosphorylation of ZAP-70 by Lck