Reactome | Recruitment of ZAP-70 to phosphorylated ITAMs

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Recruitment of ZAP-70 to phosphorylated ITAMs Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10125654
displayName	Recruitment of ZAP-70 to phosphorylated ITAMs
eventOf	[Pathway:R-RNO-202430] Translocation of ZAP-70 to Immunological synapse - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-202168] Phosphorylation of ZAP-70 by Lck - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Homo sapiens
input	[Complex:R-RNO-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-202397] ZAP70 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of ZAP-70 to phosphorylated ITAMs
output	[Complex:R-RNO-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
precedingEvent	[Reaction:R-RNO-202165] Phosphorylation of ITAM motifs in CD3 complexes - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-202344
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-202430] Translocation of ZAP-70 to Immunological synapse
(precedingEvent)	[Reaction:R-RNO-202168] Phosphorylation of ZAP-70 by Lck
(inferredTo)	[Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs

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