Reactome | Phosphorylation of ITAM motifs in CD3 complexes

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Phosphorylation of ITAM motifs in CD3 complexes Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
catalystActivity	[CatalystActivity:202294] protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202165
displayName	Phosphorylation of ITAM motifs in CD3 complexes
eventOf	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains - Homo sapiens
followingEvent	[Reaction:R-HSA-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases - Homo sapiens [Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Homo sapiens
input	[Complex:R-HSA-202266] Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] 20 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202217] T cell receptor signaling: beyond complex complexes [LiteratureReference:212485] T-cell signalling and immune system disorders
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Phosphorylation of ITAM motifs in CD3 complexes
orthologousEvent	[Reaction:R-XTR-202165] Phosphorylation of ITAM motifs in CD3 complexes - Xenopus tropicalis [Reaction:R-SSC-202165] Phosphorylation of ITAM motifs in CD3 complexes - Sus scrofa [Reaction:R-BTA-202165] Phosphorylation of ITAM motifs in CD3 complexes - Bos taurus [Reaction:R-CFA-202165] Phosphorylation of ITAM motifs in CD3 complexes - Canis familiaris [Reaction:R-RNO-202165] Phosphorylation of ITAM motifs in CD3 complexes - Rattus norvegicus [Reaction:R-MMU-202165] Phosphorylation of ITAM motifs in CD3 complexes - Mus musculus
output	20 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
precedingEvent	[Reaction:R-HSA-202291] Activation of Lck - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202165
summation	[Summation:202232] The autophosphorylated, active Lck is now proximally positio...

Referrals

(precedingEvent)	[Reaction:R-HSA-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases [Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs
(hasEvent)	[Pathway:R-HSA-202427] Phosphorylation of CD3 and TCR zeta chains