Reactome | Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]

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Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases - Homo sapiens [Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Homo sapiens
created	[InstanceEdit:203492] Garapati, P V, 2007-11-13 17:32:15
dbId	203494
displayName	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-167542] CD4 [plasma membrane] [Complex:R-HSA-203463] MHC Class II bearing antigen peptide [plasma membrane] [EntityWithAccessionedSequence:R-HSA-202308] p-Y394-LCK [cytosol] [Complex:R-HSA-203493] T-cell receptor complex with phosphorylated ITAMs [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Mus musculus [Complex:R-RNO-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Canis familiaris [Complex:R-BTA-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Bos taurus [Complex:R-SSC-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Sus scrofa [Complex:R-XTR-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - Xenopus tropicalis
maxDepth	5
name	Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4
producedByEvent	[Reaction:R-HSA-202165] Phosphorylation of ITAM motifs in CD3 complexes - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-203494
updateTrackers	[UpdateTracker:9869198] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v33:[updateContainedComponent] [UpdateTracker:9953907] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v93:[updateContainedComponent] [UpdateTracker:9903307] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9872431] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9870047] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v37:[updateContainedComponent] [UpdateTracker:9899163] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v65:[updateContainedComponent] [UpdateTracker:9869673] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v34:[updateContainedComponent] [UpdateTracker:9900980] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v71:[updateContainedComponent] [UpdateTracker:9868697] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v32:[updateContainedComponent] [UpdateTracker:9904649] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v84:[updateContainedComponent] [UpdateTracker:9873293] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v42:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9869198] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v33:[updateContainedComponent] [UpdateTracker:9953907] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v93:[updateContainedComponent] [UpdateTracker:9903307] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9872431] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9870047] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v37:[updateContainedComponent] [UpdateTracker:9899163] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v65:[updateContainedComponent] [UpdateTracker:9869673] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v34:[updateContainedComponent] [UpdateTracker:9900980] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v71:[updateContainedComponent] [UpdateTracker:9868697] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v32:[updateContainedComponent] [UpdateTracker:9904649] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v84:[updateContainedComponent] [UpdateTracker:9873293] Update Tracker - [Complex:203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] - v42:[updateContainedComponent]
(input)	[Reaction:R-HSA-389758] Dephosphorylation of CD3-zeta by PD-1 bound phosphatases [Reaction:R-HSA-202344] Recruitment of ZAP-70 to phosphorylated ITAMs
(output)	[Reaction:R-HSA-202165] Phosphorylation of ITAM motifs in CD3 complexes
(hasComponent)	[Complex:R-HSA-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] [Complex:R-HSA-202345] phospho tyrosine ZAP-70 [plasma membrane] [Complex:R-HSA-202181] Activated ZAP-70 [plasma membrane]

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