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Recruitment of ZAP-70 to phosphorylated ITAMs
Stable Identifier
R-HSA-202344
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
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Phosphorylation of the ITAMs by Lck is followed by the recruitment of the ZAP-70 a member of Syk family PTK, to the receptor complex. ZAP-70 is exclusively expressed in T cells and NK cells. The dually phosphorylated ITAMs provide a high-affinity docking site for the tandem SH2-domains of the ZAP-70. Once recruited, ZAP-70 is activated by phosphorylation and will be responsible for the phosphorylation of further downstream molecules. Due to the presence of 10 ITAMs in the TCR complex, up to 10 ZAP-70 molecules may cluster on the fully phosphorylated receptors.
Literature References
PubMed ID
Title
Journal
Year
9850860
The Syk family of protein tyrosine kinases in T-cell activation and development
Chu, DH
,
Morita, CT
,
Weiss, A
Immunol Rev
1998
8520027
The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes
van Oers, NS
,
Weiss, A
Semin Immunol
1995
12485116
Positive and negative regulation of T-cell activation through kinases and phosphatases
Tasken, K
,
Mustelin, T
Biochem J
2003
Participants
Input
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane]
(Homo sapiens)
ZAP70 [cytosol]
(Homo sapiens)
Output
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
(Homo sapiens)
Participates
as an event of
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Orthologous Events
Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-29)
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