Recruitment of ZAP-70 to phosphorylated ITAMs

Stable Identifier
R-HSA-202344
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylation of the ITAMs by Lck is followed by the recruitment of the ZAP-70 a member of Syk family PTK, to the receptor complex. ZAP-70 is exclusively expressed in T cells and NK cells. The dually phosphorylated ITAMs provide a high-affinity docking site for the tandem SH2-domains of the ZAP-70. Once recruited, ZAP-70 is activated by phosphorylation and will be responsible for the phosphorylation of further downstream molecules. Due to the presence of 10 ITAMs in the TCR complex, up to 10 ZAP-70 molecules may cluster on the fully phosphorylated receptors.

Literature References
PubMed ID Title Journal Year
8520027 The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

van Oers, NS, Weiss, A

Semin Immunol 1995
9850860 The Syk family of protein tyrosine kinases in T-cell activation and development

Chu, DH, Morita, CT, Weiss, A

Immunol Rev 1998
12485116 Positive and negative regulation of T-cell activation through kinases and phosphatases

Mustelin, T, Tasken, K

Biochem J 2003
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