Reactome | Formation of the beta-catenin:TCF transactivating complex

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Formation of the beta-catenin:TCF transactivating complex Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912646
displayName	Formation of the beta-catenin:TCF transactivating complex
eventOf	[Pathway:R-DME-201681] TCF dependent signaling in response to WNT - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8854802] beta-catenin-TCF complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Drosophila melanogaster [Reaction:R-DME-3322427] Beta-catenin recruits CBP/p300 - Drosophila melanogaster [Reaction:R-DME-3322424] Beta-catenin recruits CDC73 and LEO1 - Drosophila melanogaster [Reaction:R-DME-3364014] Recruitment of MLL2 methyltransferase complex - Drosophila melanogaster [Reaction:R-DME-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of the beta-catenin:TCF transactivating complex
precedingEvent	[BlackBoxEvent:R-DME-201669] Beta-catenin translocates to the nucleus - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-201722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex

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