Reactome | Formation of the beta-catenin:TCF transactivating complex

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Formation of the beta-catenin:TCF transactivating complex Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444130
displayName	Formation of the beta-catenin:TCF transactivating complex
eventOf	[Pathway:R-BTA-201681] TCF dependent signaling in response to WNT - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8854802] beta-catenin-TCF complex assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF - Bos taurus [Reaction:R-BTA-201712] Beta-catenin:TCF associates with BCL9 and PYGO - Bos taurus [Reaction:R-BTA-3322427] Beta-catenin recruits CBP/p300 - Bos taurus [Reaction:R-BTA-3322424] Beta-catenin recruits CDC73 and LEO1 - Bos taurus [Reaction:R-BTA-3322422] Beta-catenin recruits SMARCA4 - Bos taurus [Reaction:R-BTA-3364014] Recruitment of MLL2 methyltransferase complex - Bos taurus [Reaction:R-BTA-3364026] MLL2 complex trimethylates H3K4 at the MYC gene - Bos taurus [Reaction:R-BTA-3451153] Beta-catenin recruits TRRAP/KAT5 HAT components - Bos taurus
inferredFrom	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of the beta-catenin:TCF transactivating complex
precedingEvent	[BlackBoxEvent:R-BTA-201669] Beta-catenin translocates to the nucleus - Bos taurus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-201722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex

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