Reactome | K63polyUb-APC [cytosol]

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K63polyUb-APC [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6781912] ZRANB1:K63polyUb-APC [cytosol] - Homo sapiens [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6781905] ZRANB1 binds APC - Homo sapiens [FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex - Homo sapiens [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex - Homo sapiens [Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens
created	[InstanceEdit:5246689] Rothfels, K, 2014-01-22
dbId	5246690
displayName	K63polyUb-APC [cytosol]
endCoordinate	2843
hasModifiedResidue	[GroupModifiedResidue:5246646] ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-5246690] Apc [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-5246690] Apc [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-5246690] APC [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-5246690] APC [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-5246690] APC [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-5246690] apc [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-5246690] APC [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-5246690] Apc [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-5246690-2] Apc2 [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-5246690-3] Homologues of K63polyUb-APC [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-5246690] apr-1 [cytosol] - Caenorhabditis elegans
modified	[InstanceEdit:6781948] Jupe, Steve, 2015-06-03
name	K63polyUb-APC Adenomatous polyposis coli protein APC_HUMAN
producedByEvent	[Reaction:R-HSA-5246693] APC is K63-polyubiquitinated - Homo sapiens [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex - Homo sapiens
referenceEntity	[ReferenceGeneProduct:403429] UniProt:P25054 APC
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-5246690
startCoordinate	1

Referrals

(input)	[FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex [Reaction:R-HSA-6781905] ZRANB1 binds APC [Reaction:R-HSA-195251] Assembly of the destruction complex
(normalEntity)	[EntityFunctionalStatus:4791276] loss_of_function of APC truncation mutants [cytosol]
(hasComponent)	[Complex:R-HSA-6781912] ZRANB1:K63polyUb-APC [cytosol] [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(output)	[Reaction:R-HSA-5246693] APC is K63-polyubiquitinated [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex

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