Reactome | PP2A [cytosol]

Schema > Complex > Entries

PP2A [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:390328] phosphatidate phosphatase activity of PP2A [cytosol] [CatalystActivity:5672955] protein serine/threonine phosphatase activity of PP2A [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-432144] p-PECAM:PP2A [plasma membrane] - Homo sapiens [Complex:R-HSA-5339714] p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] - Homo sapiens [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - Homo sapiens [Complex:R-HSA-375305] Kinetochore [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-389532] PP2A binds CTLA4 dimer - Homo sapiens [Reaction:R-HSA-8857925] Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 - Homo sapiens [Reaction:R-HSA-432143] PECAM-1 binds PP2A - Homo sapiens [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex - Homo sapiens [FailedReaction:R-HSA-4791278] APC truncation mutants have impaired AXIN binding - Homo sapiens [Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens [FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex - Homo sapiens
created	[InstanceEdit:196217] Matthews, L, 2007-04-18 13:41:15
dbId	196206
displayName	PP2A [cytosol]
hasComponent	[CandidateSet:R-HSA-196216] PP2A regulatory subunit B56 [cytosol] [CandidateSet:R-HSA-165977] PP2A-catalytic subunit C [cytosol] [CandidateSet:R-HSA-165990] PP2A-subunit A [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-196206] PP2A [cytosol] - Mus musculus [Complex:R-RNO-196206] PP2A [cytosol] - Rattus norvegicus [Complex:R-CFA-196206] PP2A [cytosol] - Canis familiaris [Complex:R-BTA-196206] PP2A [cytosol] - Bos taurus [Complex:R-SSC-196206] PP2A [cytosol] - Sus scrofa [Complex:R-DRE-196206] PP2A [cytosol] - Danio rerio [Complex:R-XTR-196206] PP2A [cytosol] - Xenopus tropicalis [Complex:R-GGA-196206] PP2A [cytosol] - Gallus gallus [Complex:R-DME-196206] PP2A [cytosol] - Drosophila melanogaster [Complex:R-CEL-196206] PP2A [cytosol] - Caenorhabditis elegans [Complex:R-DDI-196206] PP2A [cytosol] - Dictyostelium discoideum [Complex:R-SPO-196206] PP2A [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-196206] PP2A [cytosol] - Saccharomyces cerevisiae
maxDepth	3
modified	[InstanceEdit:196230] Matthews, L, 2007-04-19 08:03:24
name	PP2A
producedByEvent	[Reaction:R-HSA-388833] Phosphorylation of CTLA-4 - Homo sapiens [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-196206
updateTrackers	[UpdateTracker:9878952] Update Tracker - [Complex:196206] PP2A [cytosol] - v44:[updateContainedComponent] [UpdateTracker:9873599] Update Tracker - [Complex:196206] PP2A [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9871286] Update Tracker - [Complex:196206] PP2A [cytosol] - v39:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9878952] Update Tracker - [Complex:196206] PP2A [cytosol] - v44:[updateContainedComponent] [UpdateTracker:9873599] Update Tracker - [Complex:196206] PP2A [cytosol] - v43:[updateContainedComponent] [UpdateTracker:9871286] Update Tracker - [Complex:196206] PP2A [cytosol] - v39:[updateContainedComponent]
(input)	[FailedReaction:R-HSA-4839734] AXIN mutants destabilize the destruction complex [FailedReaction:R-HSA-4839746] Truncated AMER1 mutants destabilize the destruction complex [FailedReaction:R-HSA-4791278] APC truncation mutants have impaired AXIN binding [Reaction:R-HSA-432143] PECAM-1 binds PP2A [Reaction:R-HSA-389532] PP2A binds CTLA4 dimer [Reaction:R-HSA-195251] Assembly of the destruction complex [Reaction:R-HSA-8857925] Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
(hasComponent)	[Complex:R-HSA-5339714] p-AXIN:GSK3 del304-316:CK1alpha:APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-432144] p-PECAM:PP2A [plasma membrane] [Complex:R-HSA-196222] p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-195322] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-195297] p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] [Complex:R-HSA-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Complex:R-HSA-389533] CTLA4 dimer:PP2A [plasma membrane] [Complex:R-HSA-375305] Kinetochore [cytosol]
(physicalEntity)	[CatalystActivity:390328] phosphatidate phosphatase activity of PP2A [cytosol] [CatalystActivity:5672955] protein serine/threonine phosphatase activity of PP2A [cytosol]
(output)	[Reaction:R-HSA-388833] Phosphorylation of CTLA-4 [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex
(activeUnit)	[CatalystActivity:3601580] protein serine/threonine phosphatase activity of p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]

© 2026 Reactome

Cite Us!