Reactome | NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

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NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD Show undefined attributes

catalystActivity	[CatalystActivity:10351520] nicotinate-nucleotide adenylyltransferase activity of 4xNMNAT3:4xMg2+ [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10351522
displayName	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
eventOf	[Pathway:R-BTA-196807] Nicotinate metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-8938083] NAMN [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD beta-nicotinamide D-ribonucleotide + ATP + H(+) => diphosphate + NAD(+) Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
output	[SimpleEntity:R-ALL-8938090] NAAD [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-BTA-197268] QPRT transfers PRIB to QUIN to form NAMN - Bos taurus [Reaction:R-BTA-197250] NAMPT transfers PRIB to NAM to form NAMN - Bos taurus [Reaction:R-BTA-8869606] NMRK1 phosphorylates NAR to yield NAMN - Bos taurus [Reaction:R-BTA-8869607] NMRK2 phosphorylates NAR to yield NAMN - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-200474
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-200474] NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD

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