Reactome | p-S183,S221,T246-AKT1S1 [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5672861] p-S183,S221,T246-AKT1S1:YWHAB [lysosomal membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5672824] Phosphorylated AKT1S1 binds YWHAB - Homo sapiens
created	[InstanceEdit:200149] Jassal, B, 2007-07-16 08:38:43
dbId	200163
deleted	[Deleted:9763792] Deletion of instance: 5672863
displayName	p-S183,S221,T246-AKT1S1 [cytosol]
endCoordinate	256
hasModifiedResidue	[ModifiedResidue:377446] O-phospho-L-serine at 183 [ModifiedResidue:200159] O-phospho-L-threonine at 246 [ModifiedResidue:200144] O-phospho-L-serine at 221
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-200163] phospho-Akt1s1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-200163] phospho-Akt1s1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-200163] phospho-AKT1S1 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-200163] phospho-AKT1S1 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-200163] phospho-AKT1S1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-200163] phospho-akt1s1 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-200163] phospho-akt1s1 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-DME-200163] phospho-PRAS40 [cytosol] - Drosophila melanogaster
maxDepth	1
modified	[InstanceEdit:9975254] Orlic-Milacic, Marija, 2025-11-29
name	p-S183,S221,T246-AKT1S1 p-S183,S221,T246-PRAS40 Phospho-Proline-rich AKT1 substrate 1 AKTS1_HUMAN AKT1S1
producedByEvent	[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-200143] AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-5672828] mTORC1 phosphorylates AKT1S1 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q96B36] UniProt:Q96B36 AKT1S1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-200163
startCoordinate	1
updateTrackers	[UpdateTracker:9873335] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v42:[addName, modifyEndCoordinate] [UpdateTracker:9984883] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v96:[modifyName, removeHasModifiedResidue] [UpdateTracker:9867768] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v26:[add_removeHasModifiedResidue, modifyEndCoordinate] [UpdateTracker:9870616] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v38:[addName]

(updatedInstance)	[UpdateTracker:9873335] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v42:[addName, modifyEndCoordinate] [UpdateTracker:9984883] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v96:[modifyName, removeHasModifiedResidue] [UpdateTracker:9867768] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v26:[add_removeHasModifiedResidue, modifyEndCoordinate] [UpdateTracker:9870616] Update Tracker - [EntityWithAccessionedSequence:200163] p-S183,T246-AKT1S1 [cytosol] - v38:[addName]
(replacementInstances)	[Deleted:9763792] Deletion of instance: 5672863
(output)	[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) [Reaction:R-HSA-5672828] mTORC1 phosphorylates AKT1S1 [Reaction:R-HSA-200143] AKT phosphorylates AKT1S1 (PRAS40)
(hasComponent)	[Complex:R-HSA-5672861] p-S183,S221,T246-AKT1S1:YWHAB [lysosomal membrane]
(input)	[Reaction:R-HSA-5672824] Phosphorylated AKT1S1 binds YWHAB

p-S183,S221,T246-AKT1S1 [cytosol] Show undefined attributes

Referrals