Reactome | C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)

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C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) Show undefined attributes

catalystActivity	[CatalystActivity:10686059] N-acetylgalactosaminide beta-1,3-galactosyltransferase activity of C1GALT1:C1GALT1C1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10686061
displayName	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
eventOf	[Pathway:R-XTR-913709] O-linked glycosylation of mucins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-981497] ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position - Xenopus tropicalis [Reaction:R-XTR-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) - Homo sapiens
input	[DefinedSet:R-XTR-913659] Tn antigens [Golgi lumen] [SimpleEntity:R-ALL-735682] UDP-Gal [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
output	[DefinedSet:R-XTR-1462240] Core 1 mucins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-XTR-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1964505
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-913709] O-linked glycosylation of mucins
(precedingEvent)	[Reaction:R-XTR-981497] ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position [Reaction:R-XTR-914012] GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
(inferredTo)	[Reaction:R-HSA-1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)

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