Reactome | I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

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I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023945] inositol-1,4,5,6-tetrakisphosphate 3-kinase activity of IPMK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:12667486] RHEA:11857 [DatabaseIdentifier:9966592] RHEA:11857
dbId	1855185
displayName	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Homo sapiens [Reaction:R-HSA-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Homo sapiens [Reaction:R-HSA-1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023935] I(1,4,5,6)P4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889919] The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization [LiteratureReference:1889765] Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
orthologousEvent	[Reaction:R-PFA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Plasmodium falciparum [Reaction:R-DDI-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Dictyostelium discoideum [Reaction:R-CEL-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Caenorhabditis elegans [Reaction:R-DME-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Drosophila melanogaster [Reaction:R-XTR-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Xenopus tropicalis [Reaction:R-DRE-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Danio rerio [Reaction:R-BTA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Bos taurus [Reaction:R-CFA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Canis familiaris [Reaction:R-RNO-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Rattus norvegicus [Reaction:R-MMU-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-2023901] I(1,3,4,5,6)P5 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-1855189] I(1,4,5,6)P4 transports from the ER lumen to the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06 [InstanceEdit:9966625] D'Eustachio, Peter, 2025-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855185
summation	[Summation:2023928] In the nucleus, inositol polyphosphate multikinase (IPMK) ph...
updateTrackers	[UpdateTracker:9971796] Update Tracker - [Reaction:1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - v95:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9971796] Update Tracker - [Reaction:1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - v95:[removeOutput]
(hasEvent)	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[Reaction:R-HSA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus [Reaction:R-HSA-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus [Reaction:R-HSA-1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol

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