Reactome | I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus

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I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023933] inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity of IPPK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:12667485] RHEA:20314 [DatabaseIdentifier:9966591] RHEA:20314
dbId	1855176
displayName	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1855187] IP6 transports from the nucleus to the ER lumen - Homo sapiens [Reaction:R-HSA-1855207] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023901] I(1,3,4,5,6)P5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889807] The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase [LiteratureReference:1889938] Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase [LiteratureReference:1889802] Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
orthologousEvent	[Reaction:R-RNO-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Rattus norvegicus [Reaction:R-GGA-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Gallus gallus [Reaction:R-XTR-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Xenopus tropicalis [Reaction:R-DRE-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Danio rerio [Reaction:R-SSC-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Sus scrofa [Reaction:R-BTA-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Bos taurus [Reaction:R-CFA-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Canis familiaris [Reaction:R-MMU-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-2023929] IP6 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-1855160] I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus - Homo sapiens [Reaction:R-HSA-1855206] I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens [Reaction:R-HSA-1855228] I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens [Reaction:R-HSA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06 [InstanceEdit:9966625] D'Eustachio, Peter, 2025-09-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855176
summation	[Summation:2023925] In the nucleus, inositol-pentakisphosphate 2-kinase (IPPK - ...
updateTrackers	[UpdateTracker:9971934] Update Tracker - [Reaction:1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - v95:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9971934] Update Tracker - [Reaction:1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - v95:[removeOutput]
(hasEvent)	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[BlackBoxEvent:R-HSA-1855187] IP6 transports from the nucleus to the ER lumen [Reaction:R-HSA-1855207] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

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