Reactome | I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus

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I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023953] inositol-1,3,4,5,6-pentakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855181
displayName	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus - Homo sapiens
followingEvent	[Reaction:R-HSA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Homo sapiens [Reaction:R-HSA-1855173] 5-PP-IP4 transports from the nucleus to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023901] I(1,3,4,5,6)P5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase [LiteratureReference:1889872] The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis [LiteratureReference:1889876] Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
orthologousEvent	[Reaction:R-PFA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Plasmodium falciparum [Reaction:R-SCE-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Saccharomyces cerevisiae [Reaction:R-DDI-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Dictyostelium discoideum [Reaction:R-SPO-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Schizosaccharomyces pombe [Reaction:R-CEL-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Caenorhabditis elegans [Reaction:R-DME-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Drosophila melanogaster [Reaction:R-GGA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Gallus gallus [Reaction:R-XTR-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Xenopus tropicalis [Reaction:R-DRE-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Danio rerio [Reaction:R-SSC-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Sus scrofa [Reaction:R-BTA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Bos taurus [Reaction:R-CFA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Canis familiaris [Reaction:R-RNO-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Rattus norvegicus [Reaction:R-MMU-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Mus musculus
output	[SimpleEntity:R-ALL-2023922] 5-PP-IP4 [nucleoplasm] [SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-1855160] I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus - Homo sapiens [Reaction:R-HSA-1855206] I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens [Reaction:R-HSA-1855228] I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens [Reaction:R-HSA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855181
summation	[Summation:2023921] In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) a...

Referrals

(precedingEvent)	[Reaction:R-HSA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus [Reaction:R-HSA-1855173] 5-PP-IP4 transports from the nucleus to the cytosol
(hasEvent)	[Pathway:R-HSA-1855191] Synthesis of IPs in the nucleus

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