Reactome | I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

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I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10036735] inositol-1,4,5,6-tetrakisphosphate 3-kinase activity of IPMK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10036737
displayName	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
eventOf	[Pathway:R-MMU-1855191] Synthesis of IPs in the nucleus - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus - Mus musculus [Reaction:R-MMU-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Mus musculus [Reaction:R-MMU-1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol - Mus musculus
inferredFrom	[Reaction:R-HSA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023935] I(1,4,5,6)P4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-2023901] I(1,3,4,5,6)P5 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1855185
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[Reaction:R-MMU-1855176] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus [Reaction:R-MMU-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus [Reaction:R-MMU-1855161] I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
(inferredTo)	[Reaction:R-HSA-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

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