BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-1839107
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3
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Once recruited to the activated BCR-FGFR1 fusion PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling (Roumiantsev, 2004; Demiroglu, 2001).
Literature References
PubMed ID Title Journal Year
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Demiroglu, A, Steer, EJ, Heath, C, Taylor, K, Bentley, M, Allen, SL, Koduru, P, Brody, JP, Hawson, G, Rodwell, R, Doody, ML, Carnicero, F, Reiter, A, Goldman, JM, Melo, JV, Cross, NC

Blood 2001
15050920 Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

Roumiantsev, S, Krause, DS, Neumann, CA, Dimitri, CA, Asiedu, F, Cross, NC, Van Etten, RA

Cancer Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]

Physical Entity
pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Normal reaction
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Functional status

Gain of function of pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB1:PI3K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
Rhea
Mondo
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2011-10-27)
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