Reactome | pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1839045] pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2 - Homo sapiens
created	[InstanceEdit:1839042] Rothfels, K, 2011-10-27
crossReference	[DatabaseIdentifier:12020830] Mondo:0002582
dbId	1839043
disease	[Disease:1247687] chronic myeloid leukemia [Disease:1614677] myelodysplastic myeloproliferative cancer [Disease:1604519] subacute leukemia [Disease:2317476] acute lymphocytic leukemia
displayName	pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-1839041] p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]
inDisease	true
isChimeric	false
maxDepth	2
memberOf	[DefinedSet:R-HSA-1839058] cytosolic activated FGFR1 fusion mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9832769] Orlic-Milacic, Marija, 2023-04-07
name	pY177-BCR-p-FGFR1 fusion mutant dimer
producedByEvent	[Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1839043
updateTrackers	[UpdateTracker:9905345] Update Tracker - [Complex:1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] - v85:[add_removeDisease]

(updatedInstance)	[UpdateTracker:9905345] Update Tracker - [Complex:1839043] pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol] - v85:[add_removeDisease]
(output)	[Reaction:R-HSA-1839067] Phosphorylation of BCR moiety of BCR-FGFR1
(input)	[Reaction:R-HSA-1839095] p-BCR-pFGFR1 binds GRB2:GAB2
(diseaseEntity)	[EntityFunctionalStatus:5654559] gain_of_function of pY177-BCR-p-FGFR1 fusion mutant dimer [cytosol]
(hasComponent)	[Complex:R-HSA-1839045] pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] [Complex:R-HSA-1839047] pY177-BCR-pY-FGFR1 mutant:GRB2:p-GAB2 [cytosol]
(hasMember)	[DefinedSet:R-HSA-1839058] cytosolic activated FGFR1 fusion mutants [cytosol]

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