Reactome | CBL binds to GRB2

CBL binds to GRB2

Stable Identifier

R-HSA-183052

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CBL binds multiple signalling proteins including GRB2. The CBL:GRB2 complex translocates to the plasma membrane where it can bind to GRB2-specific docking sites on the EGF receptor.

Literature References

PubMed ID	Title	Journal	Year
8621719	p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase Panchamoorthy, G, Fukazawa, T, Miyake, S, Soltoff, S, Reedquist, K, Druker, B, Shoelson, S, Cantley, LC, Band, H	J Biol Chem	1996