Reactome | CBL [cytosol]

Schema > EntityWithAccessionedSequence > Entries

CBL [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-8876356] CBL:GRB2,CBL [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9818003] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] - Homo sapiens [Complex:R-HSA-1225855] Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] - Homo sapiens [Complex:R-HSA-1225855] Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-205244] Recruitment of CBL to KIT - Homo sapiens [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated - Homo sapiens [Reaction:R-HSA-1295622] SPRY2 binds CBL - Homo sapiens [BlackBoxEvent:R-HSA-182988] Sprouty lures CBL away from EGFR - Homo sapiens [Reaction:R-HSA-183052] CBL binds to GRB2 - Homo sapiens [Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens [Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens [Reaction:R-HSA-8848818] PTK6 phosphorylates CBL - Homo sapiens [Reaction:R-HSA-9817983] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL - Homo sapiens [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL - Homo sapiens [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL - Homo sapiens [Reaction:R-HSA-1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-9706293] Active FLT3 binds to CBL - Homo sapiens [Reaction:R-HSA-1112690] PTPN11 binds CBL - Homo sapiens [Reaction:R-HSA-183094] CDC42:GTP binds CBL:Beta-Pix - Homo sapiens [Reaction:R-HSA-4332235] CBL binds TGFBR2 - Homo sapiens
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
dbId	112199
displayName	CBL [cytosol]
endCoordinate	906
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-112199] CBL [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-112199] Cbl [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-112199] CBL [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-112199] CBL [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-112199] CBL [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-112199] cbl [cytosol] - Danio rerio [GenomeEncodedEntity:R-XTR-112199] Ghost homologue of CBL [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-112199] CBL [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-112199] Cbl [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-112199] sli-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-PFA-112199] CBL [cytosol] - Plasmodium falciparum
maxDepth	1
modified	[InstanceEdit:2006497] Orlic-Milacic, Marija, 2011-11-21
name	CBL CBL E3 ubiquitin protein ligase Signal transduction protein CBL Proto-oncogene c-CBL Casitas B-lineage lymphoma proto-oncogene
producedByEvent	[Reaction:R-HSA-1295621] CBL dissociates from ubiquitinated p-SPRY2 - Homo sapiens [Reaction:R-HSA-4332236] CBL neddylates TGFBR2 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P22681] UniProt:P22681 CBL
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-112199
startCoordinate	1
updateTrackers	[UpdateTracker:9871226] Update Tracker - [EntityWithAccessionedSequence:112199] CBL [cytosol] - v39:[modifyEndCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9871226] Update Tracker - [EntityWithAccessionedSequence:112199] CBL [cytosol] - v39:[modifyEndCoordinate]
(hasComponent)	[Complex:R-HSA-9818003] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] [Complex:R-HSA-1225855] Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] [Complex:R-HSA-9706252] active FLT3:CBL [plasma membrane] [Complex:R-HSA-8876350] HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] [Complex:R-HSA-205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] [Complex:R-HSA-912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Complex:R-HSA-1112744] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] [Complex:R-HSA-934572] Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] [Complex:R-HSA-934576] Y55/Y227-pSPRY2:CBL [plasma membrane] [Complex:R-HSA-182956] CBL:Beta-Pix:CDC42:GTP [cytosol] [Complex:R-HSA-182914] CBL:SPRY1/2 [cytosol] [Complex:R-HSA-182910] CBL:GRB2 [cytosol] [Complex:R-HSA-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Complex:R-HSA-4332229] TGFBR2:CBL [plasma membrane]
(input)	[Reaction:R-HSA-9817983] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL [FailedReaction:R-HSA-5637794] EGFRvIII does not bind CBL [Reaction:R-HSA-1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants [Reaction:R-HSA-9706293] Active FLT3 binds to CBL [Reaction:R-HSA-205244] Recruitment of CBL to KIT [Reaction:R-HSA-879917] CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated [Reaction:R-HSA-1112690] PTPN11 binds CBL [Reaction:R-HSA-1295622] SPRY2 binds CBL [Reaction:R-HSA-183094] CDC42:GTP binds CBL:Beta-Pix [BlackBoxEvent:R-HSA-182988] Sprouty lures CBL away from EGFR [Reaction:R-HSA-183052] CBL binds to GRB2 [Reaction:R-HSA-183055] Binding of CBL to EGFR [Reaction:R-HSA-8848818] PTK6 phosphorylates CBL [Reaction:R-HSA-4332235] CBL binds TGFBR2
(hasCandidate)	[CandidateSet:R-HSA-8876356] CBL:GRB2,CBL [cytosol]
(output)	[Reaction:R-HSA-1295621] CBL dissociates from ubiquitinated p-SPRY2 [Reaction:R-HSA-4332236] CBL neddylates TGFBR2
(activeUnit)	[CatalystActivity:934571] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane] [CatalystActivity:183057] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]

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