Reactome | Localization of CBL:GRB2 to the membrane

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Localization of CBL:GRB2 to the membrane Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
dbId	183067
displayName	Localization of CBL:GRB2 to the membrane
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent	[Reaction:R-HSA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Homo sapiens
input	2 × [Complex:R-HSA-182910] CBL:GRB2 [cytosol] [Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:183098] A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Localization of CBL:GRB2 to the membrane
negativePrecedingEvent	[NegativePrecedingEvent:9865818] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
orthologousEvent	[Reaction:R-CEL-183067] Localization of CBL:GRB2 to the membrane - Caenorhabditis elegans [Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane - Drosophila melanogaster [Reaction:R-GGA-183067] Localization of CBL:GRB2 to the membrane - Gallus gallus [Reaction:R-DRE-183067] Localization of CBL:GRB2 to the membrane - Danio rerio [Reaction:R-SSC-183067] Localization of CBL:GRB2 to the membrane - Sus scrofa [Reaction:R-BTA-183067] Localization of CBL:GRB2 to the membrane - Bos taurus [Reaction:R-CFA-183067] Localization of CBL:GRB2 to the membrane - Canis familiaris [Reaction:R-RNO-183067] Localization of CBL:GRB2 to the membrane - Rattus norvegicus [Reaction:R-MMU-183067] Localization of CBL:GRB2 to the membrane - Mus musculus
output	[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-183052] CBL binds to GRB2 - Homo sapiens [Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens [Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-183067
summation	[Summation:183028] Upon EGF stimulation and consequent EGFR phosphorylation, GR...
updateTrackers	[UpdateTracker:9778915] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v67:[add_removeInput] [UpdateTracker:9789218] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v38:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778915] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v67:[add_removeInput] [UpdateTracker:9789218] Update Tracker - [Reaction:183067] Localization of CBL:GRB2 to the membrane - v38:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-HSA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL)