Reactome | CBL binds to GRB2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10841044
displayName	CBL binds to GRB2
eventOf	[Pathway:R-DME-182971] EGFR downregulation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-183052] CBL binds to GRB2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-112199] Cbl [cytosol] [EntityWithAccessionedSequence:R-DME-74686] drk [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL binds to GRB2
output	[Complex:R-DME-182910] CBL:GRB2 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-183052
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane
(inferredTo)	[Reaction:R-HSA-183052] CBL binds to GRB2

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