Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:183074] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Homo sapiens [Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis - Homo sapiens [Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL) - Homo sapiens
created	[InstanceEdit:182919] Jassal, B, 2006-07-21 10:17:37
dbId	182953
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
hasComponent	2 × [DefinedSet:R-HSA-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-179803] p-6Y-EGFR [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-182940] p-Y371-CBL [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Mus musculus [Complex:R-RNO-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Rattus norvegicus [Complex:R-CFA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Canis familiaris [Complex:R-BTA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Bos taurus [Complex:R-SSC-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Sus scrofa [Complex:R-DRE-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Danio rerio [Complex:R-GGA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Gallus gallus [Complex:R-DME-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Caenorhabditis elegans
maxDepth	3
modified	[InstanceEdit:9824819] Orlic-Milacic, Marija, 2023-01-22
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL EGF:Phospho-EGFR (Y1069) dimer:Phospho-CBL EGF:Phospho-EGFR (Y1045) dimer:Phospho-CBL
producedByEvent	[Reaction:R-HSA-182969] Phosphorylation of CBL (EGFR:CBL) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-182953
updateTrackers	[UpdateTracker:9898500] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v64:[add_removeHasComponent] [UpdateTracker:9899915] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v67:[add_removeHasComponent, modifyName] [UpdateTracker:9870349] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9904460] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v84:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9898500] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v64:[add_removeHasComponent] [UpdateTracker:9899915] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v67:[add_removeHasComponent, modifyName] [UpdateTracker:9870349] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9904460] Update Tracker - [Complex:182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - v84:[addName]
(normalEntity)	[EntityFunctionalStatus:5637714] loss_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane]
(input)	[Reaction:R-HSA-183089] CBL binds and ubiquitinates phosphorylated Sprouty [Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis [Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL)
(hasComponent)	[Complex:R-HSA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(physicalEntity)	[CatalystActivity:183074] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(output)	[Reaction:R-HSA-182969] Phosphorylation of CBL (EGFR:CBL)

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