Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:183057] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-182990] Sprouty sequesters CBL away from active EGFR - Homo sapiens [Reaction:R-HSA-182986] CBL-mediated ubiquitination of CIN85 - Homo sapiens
created	[InstanceEdit:182919] Jassal, B, 2006-07-21 10:17:37
dbId	182961
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
hasComponent	[Complex:R-HSA-8875480] CIN85:endophilin [cytosol] [Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] [EntityWithAccessionedSequence:R-HSA-182952] EPN1 [plasma membrane] [Complex:R-HSA-182947] EPS15:HGS:STAM [cytosol] [EntityWithAccessionedSequence:R-HSA-182937] EPS15L1 [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Mus musculus [Complex:R-RNO-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Canis familiaris [Complex:R-BTA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Bos taurus [Complex:R-SSC-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Sus scrofa [Complex:R-GGA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Gallus gallus [Complex:R-DME-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Caenorhabditis elegans
maxDepth	5
modified	[InstanceEdit:9824819] Orlic-Milacic, Marija, 2023-01-22
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 EGF:Phospho-EGFR (Y1069) dimer:Phospho-CBL:CIN85:Endophilin:Epsin:Eps15R:Eps15 complex EGF:Phospho-EGFR (Y1045) dimer:Phospho-CBL:CIN85:Endophilin:Epsin:Eps15R:Eps15 complex
producedByEvent	[Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-182961
updateTrackers	[UpdateTracker:9898639] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v64:[updateContainedComponent] [UpdateTracker:9894913] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v58:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9870843] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9904745] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v84:[addName, updateContainedComponent] [UpdateTracker:9894352] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v57:[modifyName] [UpdateTracker:9899823] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v67:[modifyName, updateContainedComponent] [UpdateTracker:9897999] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v63:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9898639] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v64:[updateContainedComponent] [UpdateTracker:9894913] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v58:[add_removeHasComponent, updateContainedComponent] [UpdateTracker:9870843] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9904745] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v84:[addName, updateContainedComponent] [UpdateTracker:9894352] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v57:[modifyName] [UpdateTracker:9899823] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v67:[modifyName, updateContainedComponent] [UpdateTracker:9897999] Update Tracker - [Complex:182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - v63:[add_removeHasComponent]
(hasComponent)	[Complex:R-HSA-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane]
(input)	[Reaction:R-HSA-182990] Sprouty sequesters CBL away from active EGFR [Reaction:R-HSA-182986] CBL-mediated ubiquitination of CIN85
(physicalEntity)	[CatalystActivity:183057] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(output)	[Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis

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