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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
Stable Identifier
R-HSA-182953
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EGF:Phospho-EGFR (Y1069) dimer:Phospho-CBL, EGF:Phospho-EGFR (Y1045) dimer:Phospho-CBL
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
CBL-mediated ubiquitination of CIN85 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGFR non-clathrin mediated endocytosis (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
Sprouty sequesters CBL away from active EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
Participants
components
x 2
EGF-like ligands [extracellular region]
(Homo sapiens)
x 2
p-6Y-EGFR [plasma membrane]
(Homo sapiens)
x 2
p-Y371-CBL [cytosol]
(Homo sapiens)
Participates
as an input of
CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
EGFR non-clathrin mediated endocytosis (Homo sapiens)
Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
as an output of
Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
Inferred To
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Bos taurus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Gallus gallus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(Sus scrofa)
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