Reactome | Phosphorylation of CBL (EGFR:CBL)

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Phosphorylation of CBL (EGFR:CBL) Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:183047] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:183010] Jassal, B, 2006-07-21 10:19:47
dbId	182969
diseaseReaction	[Reaction:R-HSA-1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
displayName	Phosphorylation of CBL (EGFR:CBL)
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent	[Reaction:R-HSA-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Homo sapiens [Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis - Homo sapiens [Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:183081] Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation [LiteratureReference:183048] Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of CBL (EGFR:CBL)
orthologousEvent	[Reaction:R-RNO-182969] Phosphorylation of CBL (EGFR:CBL) - Rattus norvegicus [Reaction:R-CEL-182969] Phosphorylation of CBL (EGFR:CBL) - Caenorhabditis elegans [Reaction:R-DME-182969] Phosphorylation of CBL (EGFR:CBL) - Drosophila melanogaster [Reaction:R-GGA-182969] Phosphorylation of CBL (EGFR:CBL) - Gallus gallus [Reaction:R-DRE-182969] Phosphorylation of CBL (EGFR:CBL) - Danio rerio [Reaction:R-SSC-182969] Phosphorylation of CBL (EGFR:CBL) - Sus scrofa [Reaction:R-BTA-182969] Phosphorylation of CBL (EGFR:CBL) - Bos taurus [Reaction:R-CFA-182969] Phosphorylation of CBL (EGFR:CBL) - Canis familiaris [Reaction:R-MMU-182969] Phosphorylation of CBL (EGFR:CBL) - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
precedingEvent	[Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-182969
summation	[Summation:182991] EGF (and indeed FGF, PDGF and NGF) stimulation results in CB...

Referrals

(normalReaction)	[Reaction:R-HSA-1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
(hasEvent)	[Pathway:R-HSA-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-HSA-183089] CBL binds and ubiquitinates phosphorylated Sprouty [Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis [Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL)

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