Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10240926] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-CFA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Canis familiaris [Reaction:R-CFA-183072] EGFR non-clathrin mediated endocytosis - Canis familiaris [Reaction:R-CFA-182993] Ubiquitination of stimulated EGFR (CBL) - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10240829
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
hasComponent	2 × [DefinedSet:R-CFA-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-CFA-182940] phospho-CBL [cytosol] 2 × [EntityWithAccessionedSequence:R-CFA-179803] phospho-EGFR [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Homo sapiens
maxDepth	3
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL
producedByEvent	[Reaction:R-CFA-182969] Phosphorylation of CBL (EGFR:CBL) - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-182953
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-183089] CBL binds and ubiquitinates phosphorylated Sprouty [Reaction:R-CFA-183072] EGFR non-clathrin mediated endocytosis [Reaction:R-CFA-182993] Ubiquitination of stimulated EGFR (CBL)
(hasComponent)	[Complex:R-CFA-182961] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(physicalEntity)	[CatalystActivity:10240926] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(output)	[Reaction:R-CFA-182969] Phosphorylation of CBL (EGFR:CBL)
(inferredTo)	[Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

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