Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10572470] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-DRE-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Danio rerio [Reaction:R-DRE-182993] Ubiquitination of stimulated EGFR (CBL) - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572445
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
hasComponent	2 × [DefinedSet:R-DRE-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-DRE-182940] phospho-cbl [cytosol] 2 × [EntityWithAccessionedSequence:R-DRE-179803] phospho-p-6Y-EGFR [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] - Homo sapiens
maxDepth	3
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL
producedByEvent	[Reaction:R-DRE-182969] Phosphorylation of CBL (EGFR:CBL) - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-182953
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-183089] CBL binds and ubiquitinates phosphorylated Sprouty [Reaction:R-DRE-182993] Ubiquitination of stimulated EGFR (CBL)
(physicalEntity)	[CatalystActivity:10572470] ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]
(output)	[Reaction:R-DRE-182969] Phosphorylation of CBL (EGFR:CBL)
(inferredTo)	[Complex:R-HSA-182953] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

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